Antibody or antibody fragment capable of binding to lung-specific X protein and use thereof

US10919978B2 · kind B2 · utility

Assignee

• IMMUNOPHARMACEUTIC INSTITUTE OF HEFEI RUIDA CO., LTD. · CN

Inventors

• Zhigang Tian · Beijing, CN
• Haiming Wei · Hefei, CN
• Xiaohu Zheng · Shanghai, CN
• Rui SUN · Taipei, TW
• Weihua XIAO · Hefei, CN
• Dan Liu · Beijing, CN
• Baoru Wang · Hefei, CN

Key dates

• Filing date: May 25, 2017
• Grant date: Feb 16, 2021
• Expiry date: Oct 29, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present application provides an antibody or antibody fragment capable of binding to a lung-specific X protein and being used to treat a tumor, and a use thereof. The antibody or antibody fragment includes heavy chain CDRs having amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3 and light chain CDRs having amino acid sequences of SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6. Alternatively, the antibody or antibody fragment includes heavy chain CDRs having amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 7, and SEQ ID NO: 3 and light chain CDRs having amino acid sequences of SEQ ID NO: 8, SEQ ID NO: 5, and SEQ ID NO: 6. The antibody is a chimeric antibody.