Functional myelination of neurons
US10920194B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 3, 2017 |
| Grant date | Feb 16, 2021 |
| Priority date | — |
| Expiry date | Mar 20, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/091
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker Gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. These cells of neural crest lineage can be used to produce a dense myelin sheath on neurons which lack myelin due to genetic defect, trauma, toxin, infection, or disease process. Therefore, embodiments of the invention provide methods for preparing such cells, the cells themselves and compositions containing the cells, as well as methods for using the cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.