Low toxic tripterygium neoglycosides, preparation method and application thereof

US10925913B2 · kind B2 · utility

Assignees

• The Second Affiliated Hospital Of Guangzhou University of Chinese Medicine · CN
• Guangzhou University of Chinese Medicine · CN

Inventors

• Bo Liu · San Diego, US
• Wei Mao · Chengdu, CN
• Xusheng Liu · 流花街道, CN
• Peng Xu · Guilderland, US
• Xiaodong Han · Longbeilingcun, CN
• Wen-Li Zhou · Changsha, CN
• Fangfang Xu · Nanjing, CN
• Yuanchao Li · Shanghai, CN
• Yiqi Yang · Lincoln, US
• Jinbao Deng · Tangxia, CN
• Lilan Wu · Tangxia, CN
• Yunshan Wu · Gangshan Subdistrict, CN
• Weiying Chen · Ningbo City, CN
• Ruimin Tian · Tangxia, CN
• Jinjian Lu · Tangxia, CN
• Yuqin Zhang · Jingwei, CN

Key dates

• Filing date: Aug 30, 2017
• Grant date: Feb 23, 2021
• Expiry date: Aug 30, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2236/51
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to a low toxic tripterygium neoglycosides, which is obtained by chemically processing tripterygium glycosides and adding triptriolide. The disclosure also discloses the application of the low toxic tripterygium neoglycosides. The tripterygium neoglycosides can effectively relieve renal pathological injury and urinary protein of nephrotic syndrome, attenuate the inflammatory level of the body, have obvious treatment effect on nephrotic syndrome, and have low toxicity and persistent effect.