Pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist

US10925927B2 · kind B2 · utility

Assignees

• FORMYCON AG · DE
• SIO2 MEDICAL PRODUCTS, LLC · US
• KLINGE BIOPHARMA GMBH · DE

Inventors

• Carsten Brockmeyer · Marzling, DE
• Christopher Weikart · Auburn, US
• Murray Stephen Bennett · Bellingham, US
• Jean-Pierre Giraud · Paris, FR
• Thomas Strungmann · Munich, DE

Key dates

• Filing date: Nov 18, 2016
• Grant date: Feb 23, 2021
• Expiry date: Jun 25, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.