Composition comprising PCSK9 peptide conjugated to a Qbeta carrier and methods of using the same

US10925938B2 · kind B2 · utility

Assignees

• The USA, as represented by the Secretary, Dept. of Health and Human Services · US
• UNM RAINFOREST INNOVATIONS · US

Inventors

• Alan T. Remaley · Bethesda, US
• John T. Schiller · Silver Spring, US
• Marcelo Amar · Gaithersburg, US
• Bryce Chackerian · Albuquerque, US

Key dates

• Filing date: Jan 17, 2019
• Grant date: Feb 23, 2021
• Expiry date: Jan 17, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2795/18141
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.