Adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative, preparation method and application thereof
US10925974B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 29, 2019 |
| Grant date | Feb 23, 2021 |
| Priority date | — |
| Expiry date | Mar 16, 2039 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the present disclosure provides a method of preparing an adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative, including: activating a carboxyl group of a cysteine residue at the C-terminus of an adipose tissue-targeting polypeptide to form an acyl chloride; reacting a verbascoside with a sodium hydroxide to obtain a sodium phenolate; esterifying the acyl chloride with the sodium phenolate to form an adipose tissue-targeting polypeptide-verbascoside derivative; and reacting the adipose tissue-targeting polypeptide-verbascoside derivative with PEG-modified nanogold particles. The present disclosure further discloses an adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative and the application of the adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative in preparing a drug for the treatment of obesity. The adipose tissue-targeting polypeptide-verbascoside-nanogold particle derivative has good biocompatibility, and capable of carrying drugs into the adipocytes, thereby greatly enhancing the availability of the drug and significantly improving the targeted anti-obesity activity of the drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.