Smooth muscle specific inhibition for anti-restenotic therapy

US10925976B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Hana Totary-Jain · Wesley Chapel, US
• Andrew Marks · Larchmont, US
• Steven Marx · New York, US

Key dates

• Filing date: Nov 7, 2017
• Grant date: Feb 23, 2021
• Expiry date: Nov 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides for the incorporation of target sequences of microRNAs into the 3′UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an expression system comprising such vectors, a pharmaceutical composition comprising such vectors, as well as methods of treating or preventing cardiovascular disease by using such vectors.