Process for preparing intermediate of anti-tumor drug niraparib and intermediate thereof
US10927077B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 12, 2018 |
| Grant date | Feb 23, 2021 |
| Priority date | — |
| Expiry date | Oct 12, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a process for preparing an intermediate of anti-tumor drug niraparib and an intermediate thereof. The present invention discloses a process for preparing compound f, which comprises conducting a cyclization reaction of compound e in a solvent and in the presence of a base to give compound f. The process of the present invention does not involve the steps of catalytic reduction or catalytic coupling reaction of precious metals and chiral separation, which has advantages such as low equipment requirements, simple operation, favorable industrial production, avoiding waste liquid containing heavy metals and phosphorus, low cost and high product ee value.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.