Patent · US Active

Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof

US10927107B2 · kind B2 · utility

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1References

17Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Hong Liu · Shanghai, CN
Yiping Wang · Beijing, CN
Fei Zhao · Suzhou, CN
Jing Zhao · Shanghai, CN
Jiang Wang · Shanghai, CN
Cong Xi · Shanghai, CN
Chenglin Wu · Nanhu, CN
Hao Shen · New York, US
Xu Han · Beijing, CN
Hualiang Jiang · Shanghai, CN
Kaixian Chen · Shanghai, CN

Key dates

Filing date	Mar 29, 2017
Grant date	Feb 23, 2021
Priority date	—
Expiry date	Mar 29, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/22
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.