Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor

US10927114B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Liqi He · West Chester, US
• Sanjeev Gangwar · Foster City, US
• Shoshana L. Posy · Highland Park, US
• Yam B. Poudel · Fremont, US
• Prasanna Sivaprakasam · Lawrenceville, US

Key dates

• Filing date: Jun 17, 2020
• Grant date: Feb 23, 2021
• Expiry date: Jun 17, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.