Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors

US10927130B2 · kind B2 · utility

Assignee

• Valo Early Discovery, Inc. · US

Inventors

• Stephanos Ioannidis · Natick, US
• Adam Charles Talbot · Guilford, US
• Bruce Follows · Littleton, US
• Alexandre Joseph Buckmelter · Superior, US
• Minghua Wang · Acton, US
• Ann-Marie Campbell · Monroe, US

Key dates

• Filing date: Jul 18, 2019
• Grant date: Feb 23, 2021
• Expiry date: Jul 18, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.