Transmetalation methods for the synthesis of PET and SPECT imaging agents
US10927132B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 26, 2016 |
| Grant date | Feb 23, 2021 |
| Priority date | — |
| Expiry date | Feb 26, 2036 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/325
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.