Spore-based bio-hybrid microrobots and the automated detection system for bacterial toxins

US10927396B2 · kind B2 · utility

Assignee

• The Chinese University of Hong Kong · CN

Inventors

• Li Zhang · Chicago, US
• Yabin Zhang · Beijing, CN
• Lidong Yang · Hong Kong, CN
• Kai Fung CHAN · Hong Kong, CN
• Lin Zhang · Qiaonanxiang, CN
• Ka Kei Wu · Tai Po, CN

Key dates

• Filing date: Oct 30, 2018
• Grant date: Feb 23, 2021
• Expiry date: Nov 21, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B34/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed are materials, devices, methods and systems for the detection of target molecules in test samples using microrobots. The target molecules may be bacterial toxins. The microrobots may include biohybrid materials such as porous spore core, a middle layer coated on the spore core for the actuation and steering in a fluid and further conjugation with a functional probe, and a sensing probe anchored onto middle layer for attaching to the targeted molecules in a fluid to respond to fluorescent tracking. A system for detecting bacterial toxin, is disclosed and comprises an intelligent motion control system based on automated fluorescent recognition and detection methods, which can propel and guide the microrobots to realize the automated motion in a pre-designed path and perform the real-time monitoring when integrating with an inverted fluorescent microscope or a fluorescent emission multi-reader.