Compositions for CYP450 phenotyping using saliva samples
US10927398B2 · kind B2 · utility
1Cited by
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18Claims
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Key dates
| Filing date | Nov 30, 2016 |
| Grant date | Feb 23, 2021 |
| Priority date | — |
| Expiry date | Feb 11, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90241
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.