LDL receptor gene knockout, genetically-engineered hamster
US10932454B2 · kind B2 · utility
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Key dates
| Filing date | Feb 1, 2017 |
| Grant date | Mar 2, 2021 |
| Priority date | — |
| Expiry date | Sep 8, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0362
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a method for preparing a genetically-engineered hamster comprising in vivo knocking out an LDL receptor gene in the hamster. The LDL receptor gene is knocked out by CRISPR/CAS9 gene editing technique. The genetically-engineered hamster shows significantly high levels of blood lipids, and it thus well-suited for direct use in hyperlipidemia and arteriosclerosis studies, and is a small animal model with high similarities to human familial hypercholesterolemia. Also provided is a method for screening drugs using the genetically-engineered hamster.
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