PH-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol

US10933024B2 · kind B2 · utility

Assignee

• Evonik Operations GmbH · DE

Inventors

• Hans Baer · Brombachtal, DE
• Thomas Fuerst · Riverdale, US
• Gerhard Renner · Deggendorf, DE
• Michael J. Gottschalk · Ober-Ramstadt, DE

Key dates

• Filing date: Sep 24, 2008
• Grant date: Mar 2, 2021
• Expiry date: Mar 8, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250% by weight of a non-porous inert lubricant, 1 to 35% by weight of at least one neutral cellulosic compound and 1 to 25% by weight of at least one emulsifier, each calculated on dry weight of the polymer mixture.