Method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles
US10933028B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 3, 2018 |
| Grant date | Mar 2, 2021 |
| Priority date | — |
| Expiry date | Dec 3, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/351
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.