Patent · US Active

Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

US10934299B2 · kind B2 · utility

4Cited by

76References

20Claims

0Family size

Assignee

Valo Early Discovery, Inc. · US

Inventors

Stephanos Ioannidis · Natick, US
Adam Charles Talbot · Guilford, US
Bruce Follows · Littleton, US
Alexandre Joseph Buckmelter · Superior, US
Minghua Wang · Acton, US
Ann-Marie Campbell · Monroe, US
Darby Schmidt · Arlington, US
David Joseph Guerin · Natick, US
Justin Andrew Caravella · Cambridge, US
R. Bruce Diebold · Waltham, US
Anna Ericsson · Keyano, CA
David R. Lancia, Jr. · Boston, US

Key dates

Filing date	Jul 19, 2019
Grant date	Mar 2, 2021
Priority date	—
Expiry date	Jul 19, 2039

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.