Chimeric antigen receptors based on single domain antibodies and methods of use thereof
US10934363B2 · kind B2 · utility
11Cited by
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24Claims
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Key dates
| Filing date | Aug 10, 2016 |
| Grant date | Mar 2, 2021 |
| Priority date | — |
| Expiry date | Apr 12, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a single-domain antibody. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.