Systems, methods and control laws for cell harvesting

US10934519B2 · kind B2 · utility

Assignee

• Global Life Sciences Solutions USA LLC · US

Inventors

• Jaydeep Roy · Saratoga Springs, US
• Andrew Michael Leach · Clifton Park, US
• Weston Blaine Griffin · Niskayuna, US
• Stefan Rakuff · Clifton Park, US
• Philip Alexander Shoemaker · Scotia, US

Key dates

• Filing date: Jul 29, 2011
• Grant date: Mar 2, 2021
• Expiry date: Mar 6, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M47/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.