THz sensing of corneal tissue water content

US10939844B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Warren S. Grundfest · Los Angeles, US
• Zachary Taylor · Los Angeles, US
• James Garritano · Los Angeles, US
• Bryan Nowroozi · Oakland, US
• Neha Bajwa · Oakland, US
• Shijun Sung · Elk Grove, US

Key dates

• Filing date: Apr 17, 2017
• Grant date: Mar 9, 2021
• Expiry date: Aug 25, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B8/10
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods and apparatus for corneal imaging and sensing are provided. Apparatus capable of utilizing single or multiple frequency emissions at terahertz (THz) wavelengths to create reflectivity maps of the cornea in either a contact or non-contact modes are also provided. Methods of obtaining data from THz imaging and sensing apparatus about the corneal tissue-aqueous humor system, including information about the corneal tissue water content (CTWC) and/or the central corneal thickness (CCT) are likewise provided. Methodologies may use multiple transfer functions (frequencies) in obtaining simultaneous data about CTWC and CCT. Methods using frequency sweeping to allow for determination of CTWC and CCT may also be utilized. Methods may also be used to assess CTWC using multiple bandwidths at the same frequency, or multiple frequencies at the same bandwidth. Methods may use data from CTWC measurements to aid in the diagnosis of various corneal and brain disorders.