Methods, systems, and apparatuses for tissue ablation using pulse shape designs

US10939949B2 · kind B2 · utility

Assignees

• INTERSCIENCE · US
• RM2 TECHNOLOGY LLC · US

Inventors

• Boris Rubinsky · Givatayim, IL
• Paul Mikus · Irvine, US
• Liel Rubinsky · Corona, US
• Michael Klaus Stehling · Rödermark, DE
• Enric Günther · Hattersheim, DE

Key dates

• Filing date: May 13, 2015
• Grant date: Mar 9, 2021
• Expiry date: Nov 13, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2018/1266
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site.