Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27

US10940150B2 · kind B2 · utility

Assignee

• Technische Universitaet Dresden · DE

Inventors

• Michael Schroeder · Hankinson, US
• Yixin Zhang · Dresden, DE
• Joerg-Christian Heinrich · Dresden, DE
• Joachim Haupt · Freiberg, DE
• Sainitin Donakonda · Darsi, IN
• Petra Lennig · Mainz, DE

Key dates

• Filing date: Jul 28, 2015
• Grant date: Mar 9, 2021
• Expiry date: Jul 31, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.