Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
US10940161B2 · kind B2 · utility
6Cited by
9References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 4, 2017 |
| Grant date | Mar 9, 2021 |
| Priority date | — |
| Expiry date | Aug 9, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.