Polyphosphazene delivery system for inorganic nanocrystals

US10940217B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• The Penn State Research Foundation · US

Inventors

• David Cormode · Philadelphia, US
• Peter Chhour · Wayne, US
• Andrew Tsourkas · Via Enrico Fermi, US
• Harry R. Allcock · State College, US
• Rabe'e Cheheltani · Philadelphia, US

Key dates

• Filing date: Mar 18, 2015
• Grant date: Mar 9, 2021
• Expiry date: Mar 18, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/1098
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoclusters comprising inorganic nanocrystals and a biodegradable polymer are disclosed. The inorganic nanocrystals have a mean particle size of 1 to 500 nm. The inorganic nanocrystals are contained within a core of the nanoclusters, on the surface of the nanoclusters, contained within a core of the nanoclusters, dispersed throughout the nanoclusters, or a combination thereof. The biodegradable polymer allows the inorganic nanocrystals to be excreted renally over a period of time. The nanoclusters can be used for medical imaging or other biomedical applications.