Patent · US Active

Benzothiadiazepine compounds and their use as bile acid modulators

US10941127B2 · kind B2 · utility

21Cited by

59References

14Claims

0Family size

Assignee

ALBIREO AB · SE

Inventors

Per-Göran Gillberg · Timrå, SE
Jan Mattsson · Gothenburg, SE
Ingemar Starke · Gothenburg, SE
Santosh S. Kulkarni · Kanchinakote, IN

Key dates

Filing date	Feb 28, 2020
Grant date	Mar 9, 2021
Priority date	—
Expiry date	Feb 28, 2040

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P1/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.