Patent · US Active

Fusion protein comprising three binding domains to 5T4 and CD3

US10941207B2 · kind B2 · utility

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0References

7Claims

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Assignee

CHIOME BIOSCIENCE INC. · JP

Inventors

Nico Mertens · Melsele, BE
Philip Jeffrey Cunnah · Cascais, PT
Ana Rita Da Fonseca Ricardo · Cascais, PT

Key dates

Filing date	Dec 21, 2015
Grant date	Mar 9, 2021
Priority date	—
Expiry date	Apr 20, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a bispecific binding molecule comprising three binding domains, wherein a first and/or a second binding domain are capable of binding to the extracellular 5T4 antigen and the remaining binding domain(s) is (are) capable of binding to the CD3 receptor complex on T cells. Moreover, the invention relates to a nucleic acid sequence encoding fusion protein, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates to a process for the production of the fusion protein of the invention, a medical use of said fusion protein and a kit comprising said fusion protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.