Chemically modified single-stranded RNA-editing oligonucleotides
US10941402B2 · kind B2 · utility
10Cited by
1References
22Claims
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Key dates
| Filing date | Aug 31, 2017 |
| Grant date | Mar 9, 2021 |
| Priority date | — |
| Expiry date | Aug 31, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y305/04004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.