Substrates and methods useful in sequencing
US10941439B2 · kind B2 · utility
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15References
12Claims
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Key dates
| Filing date | Oct 31, 2018 |
| Grant date | Mar 9, 2021 |
| Priority date | — |
| Expiry date | Oct 31, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6874
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling site, and a functional moiety coupled between the terminal end of the oligonucleotide and the coupling site. Such a hydrogel network can be formed by a method including activating a coupling site of a substrate and binding a linker moiety coupled to a terminal end of an oligonucleotide to the activated coupling site, a functional moiety coupled between the terminal end of the oligonucleotide and the linker moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.