Genetically modified non-human animal with human or chimeric PD-L1

US10945418B2 · kind B2 · utility

Assignee

• Biocytogen Pharmaceuticals (Beijing) Co., Ltd. · CN

Inventors

• Yuelei Shen · Beijing, CN
• Yang Bai · Beijing, CN
• Yanan Guo · Beijing, CN
• Rui Huang · Beijing, CN
• Xiaofei Zhou · Beijing, CN
• Chaoshe Guo · Beijing, CN

Key dates

• Filing date: May 31, 2019
• Grant date: Mar 16, 2021
• Expiry date: May 31, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/8509
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof. In one aspect, the disclosure relates to genetically-modified, non-human animals whose genome comprises at least one chromosome comprising a sequence encoding a human or chimeric programmed death-ligand 1 (PD-L1).