Memantine transdermal delivery systems
US10945968B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2017 |
| Grant date | Mar 16, 2021 |
| Priority date | — |
| Expiry date | Apr 19, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.