Compositions and methods for selective phagocytosis of human cancer cells
US10946042B2 · kind B2 · utility
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2References
36Claims
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Key dates
| Filing date | Dec 1, 2016 |
| Grant date | Mar 16, 2021 |
| Priority date | — |
| Expiry date | Apr 13, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods that provide novel therapies in cancer. The invention includes a phagocytic cell modified with a repressor of signal regulatory protein-alpha (SIRPα) and bound to a targeting antibody to enhance phagocytic activity of the phagocytic cell toward tumor tissue. Methods of enhancing phagocytic activity and treating a tumor are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.