Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts

US10946056B2 · kind B2 · utility

Assignee

• University of South Florida · US

Inventors

• Norma A. Alcantar · Tampa, US
• David Morgan · Scottsdale, US
• Zeinab Veisi · Tampa, US
• Leonid Breydo · Tampa, US
• Vladimir N. Uversky · Tampa, US
• Ryan G. Toomey · Tampa, US
• Tunan Peng · Land O' Lakes, US
• Eva Stephanie Lobbens · Farum, DK

Key dates

• Filing date: Jul 3, 2019
• Grant date: Mar 16, 2021
• Expiry date: Dec 8, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2236/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.