2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, composition, and method for improving function of aortic endothelial cell

US10947179B2 · kind B2 · utility

Assignee

• XI'AN JIAOTONG UNIVERSITY · CN

Inventors

• Jian Liu · Xi'an, CN
• Xu Liu · Santa Cruz, US
• YA-CHONG HU · Xi'an, CN
• Lin Zhao · Anshan City, CN
• Yong Wang · 安丰镇, CN
• CAI-YUE ZHU · Xi'an, CN
• Zhen Wang · Shanghai, CN
• Jing Lou · San Francisco, US
• Qing Ma · Durham, US
• Yu Zhang · Sichuan, CN
• Qing Jiang · Xi'an, CN
• Xiao XU · Suzhou, CN
• Ting Zhang · Princeton Junction, US
• JIAN-GANG LONG · Xi'an, CN

Key dates

• Filing date: Sep 26, 2019
• Grant date: Mar 16, 2021
• Expiry date: Sep 26, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/675
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.