Patent · US Active

Bryostatin compounds and methods of preparing the same

US10947221B2 · kind B2 · utility

1Cited by

6References

22Claims

0Family size

Assignee

Board of Trustees of the Leland Stanford Junior University · US

Inventors

Paul A. Wender · Menlo Park, US
Ryan Quiroz · Boston, US
Stephen Ho · New York, US
Akira Shimizu · Kyoto, JP
Steven Ryckbosch · Albany, US
Matthew C. Stevens · Atherton, US
Matthew S. Jeffreys · King of Prussia, US
Clayton Hardman · San Francisco, US
Jack Sloane · Stanford, US

Key dates

Filing date	Sep 28, 2017
Grant date	Mar 16, 2021
Priority date	—
Expiry date	Sep 28, 2037

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.