Functionalized protein-based materials and their uses

US10947282B2 · kind B2 · utility

Assignees

• THE TEXAS A&M UNIVERSITY SYSTEM · US
• William Marsh Rice University · US

Inventors

• Sarah E. Bondos · College Station, US
• Kayla Bayless · Bryan, US
• Kathleen S. Matthews · Houston, US
• Jan Patterson · College Station, US
• Colette Abbey · College Station, US
• David W. Howell · Oak Ridge, US
• Hao-Ching Hsiao · San Diego, US
• Kelly Churion · College Station, US
• Shang-Pu Tsai · Bangor, US
• Sandhya Ramasamy · Katy, US
• Dustin Porterpan · Kingwood, US
• Keira Northern · Houston, US

Key dates

• Filing date: Jan 20, 2016
• Grant date: Mar 16, 2021
• Expiry date: Jan 20, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/195
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.