Compositions targeting 3-repeat tau for the treatment of neurodegenerative disorders, and methods for making and using them

US10947302B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Eliezer Masliah · San Diego, US
• Brian Spencer · San Diego, US
• Edward Rockenstein · San Diego, US

Key dates

• Filing date: Nov 3, 2017
• Grant date: Mar 16, 2021
• Expiry date: Dec 5, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/7047
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In alternative embodiments, provided are compositions such as antibodies, e.g., single chain antibodies, that target 3-repeat (3R) Tau for the treatment of neurodegenerative disorders and taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation, and methods for making and using them. In alternative embodiments, provided are brain-penetrating antibodies that specifically recognize 3R Tau, and methods of using them to treat, ameliorate, prevent or decrease the symptoms of neurodegenerative disorders including taupathies such as Alzheimer's Disease (AD), Pick's Disease (PiD) and Fronto-temporal lobar degeneration (FTLD), or any disorder or condition associated with a 3R Tau accumulation. Provided are methods for diagnosing a neurodegenerative disorder or a taupathy or any disorder or condition associated with a 3R Tau accumulation, and optionally the taupathy is Alzheimer's Disease, Pick's Disease or Fronto-temporal lobar degeneration.