Functional, segregated, charged telodendrimers and nanocarriers and methods of making and using same

US10947350B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Juntao Luo · Jamesville, US
• Xu Wang · Jinan, CN
• Changying Shi · Jamesville, US

Key dates

• Filing date: Sep 12, 2016
• Grant date: Mar 16, 2021
• Expiry date: Oct 10, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2650/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.