Materials and methods utilizing biotin producing mutant hosts for the production of 7-carbon chemicals
US10947570B2 · kind B2 · utility
0Cited by
5References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 2017 |
| Grant date | Mar 16, 2021 |
| Priority date | — |
| Expiry date | Jul 25, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are methods for regulating biosynthesis of at least one of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, 7-aminoheptanoland 1,7-heptanediol (C7 building blocks) using a pathway having a pimeloyl-ACP intermediate, the method including the step of downregulating the activity of BioF. Also disclosed are recombinant hosts by fermentation in which the above methods are performed. Further disclosed are recombinant hosts for producing pimeloyl-ACP, the recombinant host including a deletion of a bioF gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.