Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease

US10953027B2 · kind B2 · utility

Assignee

• Flagship Pioneering Innovations VI, LLC · US

Inventors

• Steven John Taylor · Winchester, US
• John Proudfoot · Newtown, US
• Mi Jeong Kim · Hwaseong-si, KR
• Kathleen Nudel · Brookline, US
• Timothy F. BRIGGS · Waltham, US
• Afrand KAMALI SARVESTANI · Somerville, US
• Leonard Buckbinder · Doylestown, US
• Bernard LANTER · Somerville, US
• Ferdinand Edward MASSARI · Beverly, US
• Koji YASUDA · Boston, US
• Spencer Cory PECK · Watertown, US
• Cheri Snedeker · Nashua, US
• Diana LE · Reading, US
• Jessica ALEXANDER · Waltham, US
• Anna LIANG · Everett, US
• Dinara GUNASEKERA · Cambridge, US
• David Arthur Berry · Brookline, US
• John Patrick CASEY, JR. · Boston, US

Key dates

• Filing date: Feb 27, 2020
• Grant date: Mar 23, 2021
• Expiry date: Feb 27, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D407/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.