Patent · US Active

Compositions comprising a metal source, dithiocarbamate and cyclodextrin

US10953099B2 · kind B2 · utility

0Cited by

2References

5Claims

0Family size

Assignee

DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS · DE

Inventors

Eberhard Amtmann · Heidelberg, DE
Nikolas Gunkel · Heidelberg, DE
Aubry Miller · San Francisco, US
Michael M. Morgen · Bend, US

Key dates

Filing date	Oct 13, 2017
Grant date	Mar 23, 2021
Priority date	—
Expiry date	Oct 13, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F1/005
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.