Pyrazole derivatives as MALT1 inhibitors

US10954214B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Tianbao Lu · Collegeville, US
• Brett D. Allison · Del Mar, US
• Joseph Kent Barbay · Flourtown, US
• Peter J. Connolly · New Providence, US
• Maxwell D. Cummings · Strafford, US
• Gaston Stanislas Marcella Diels · Turnhout, BE
• James P. Edwards · San Diego, US
• Kevin D. Kreutter · Plainsboro, US
• Ulrike PHILIPPAR · Ekeren, BE
• Fang Shen · Amherst, US
• Johannes Wilhelmus John F. Thuring · Ekeren, BE
• Tongfei Wu · Leuven, BE
• Didier Jean-Claude Berthelot · Edegem, BE

Key dates

• Filing date: Dec 20, 2017
• Grant date: Mar 23, 2021
• Expiry date: Dec 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.