Hybrid cyclic libraries and screens thereof

US10954273B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Jun O. Liu · Clarksville, US
• Jingxin Wang · Baltimore, US
• Zufeng Guo · Baltimore, US
• Wei Li · Shanghai, CN
• Shridhar Bhat · Cockeysville, US
• Manisha Das · Centreville, US

Key dates

• Filing date: Sep 6, 2019
• Grant date: Mar 23, 2021
• Expiry date: Sep 6, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/566
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.