Patent · US Active

7Beta-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid

US10954494B2 · kind B2 · utility

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1References

2Claims

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Assignee

PHARMAZELL GMBH · DE

Inventors

Dirk Weuster-Botz · Munich, DE
Michael Braun · Heidelberg, DE
Arno Aigner · Bad Aibling, DE
Boqiao Sun · Munich, DE
Christina Kantzow · Munich, DE
Sven Bresch · Munich, DE
Daniel Bakonyi · Cologne, DE
Werner Hummel · Titz, DE

Key dates

Filing date	Apr 7, 2016
Grant date	Mar 23, 2021
Priority date	—
Expiry date	May 28, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y101/01201
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences which encode these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, in particular in the preparation of ursodeoxycholic acid (UDCS). The invention also relates to novel processes for the synthesis of UDCS using the enzyme mutants; and to the preparation of UDCS using recombinant, multiply-modified microorganisms.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.