RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
US10954513B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jun 17, 2016 |
| Grant date | Mar 23, 2021 |
| Priority date | — |
| Expiry date | Jun 17, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.