Method for producing hydroxy-L-pipecolic acid
US10954539B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Sep 30, 2016 |
| Grant date | Mar 23, 2021 |
| Priority date | — |
| Expiry date | Sep 30, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/09
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.