Stabilized compositions for the controlled delivery of probiotics and methods of production thereof
US10959950B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 2018 |
| Grant date | Mar 30, 2021 |
| Priority date | — |
| Expiry date | Oct 31, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/115
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stabilized composition for the controlled delivery of probiotics includes an aqueous solution of crystalloids and colloids comprised of water insoluble polymers with the ability to de-swell upon electrical charge. The composition further includes a plurality of oil droplets and a base solution. The composition further include a destabilizing solution comprising a solvent, nitrogen, a natural acid sufficient to produce a pH of about 3.0 to about 4.5, and a sufficient amount of a salt to contribute to an osmolality between about 190 mOsm/L and about 900 mOsm/L. The composition further includes a plurality of microencapsulated probiotic beads, wherein the plurality of microencapsulated probiotic beads comprises between about 0.01% to about 20% of the composition by weight.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.