Tridentate connexon and use thereof

US10960082B2 · kind B2 · utility

Assignee

• NewBio Therapeutics, Inc. · CN

Inventors

• Deqiang An · Shanghai, CN
• Nianhe Han · Newbury Park, US
• Di Zeng · Shanghai, CN
• Hang Yang · Shanghai, CN
• Peng Zhu · Tianjin, CN
• Mingzhen Li · Shanghai, CN
• Li Jian · Shanghai, CN
• Chun-Ying Yang · Taipei, TW

Key dates

• Filing date: Jul 23, 2015
• Grant date: Mar 30, 2021
• Expiry date: Sep 15, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, L-(T-A-D)n  I wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.