Crystalline forms of eravacycline

US10961190B2 · kind B2 · utility

Assignee

• Tetraphase Pharmaceuticals, Inc. · US

Inventors

• Danny LaFrance · Natick, US
• Philip C. Hogan · Watertown, US
• Yansheng Liu · Winchester, US
• Minsheng He · Andover, US
• Chi-Li Chen · Newton, US
• John Niu · Bedford, US

Key dates

• Filing date: Oct 19, 2017
• Grant date: Mar 30, 2021
• Expiry date: Oct 19, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to crystalline forms of the bis-HCI salt of a compound represented by Structural Formula 1, and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural Formula 1 described herein. The crystalline forms of the bis-HCl salt of a compound of Structural Formula 1 and compositions comprising the crystalline forms of the compound of Structural Formula 1 provided herein, in particular, crystalline Form I, crystalline Form J, crystalline Form A, and crystalline Form B, or mixtures thereof, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders. Also described herein are methods for preparing the crystalline forms (e.g., Forms I, J, B and A) of the bis-HCI salt of a compound represented by Structural Formula 1.