Substituted piperidinyl tetrahydroquinolines

US10961221B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Eva Maria Becker-Pelster · Wuppertal, DE
• Philipp Buchgraber · Leverkusen, DE
• Anja Buchmüller · Essen, DE
• Karen Engel · Waldkraiburg, DE
• Volker Geiss · Ratingen, DE
• Andreas Göller · Wuppertal, DE
• Herbert Himmel · Essen, DE
• Raimund Kast · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Dieter Lang · Velbert, DE
• Gorden Redlich · Bochum, DE
• Carsten Schmeck · Wuppertal, DE
• Hanna Tinel · Wuppertal, DE
• Frank Wunder · Wuppertal, DE

Key dates

• Filing date: Dec 19, 2017
• Grant date: Mar 30, 2021
• Expiry date: Dec 19, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.